



ROCKIT

ROCKIT uses maximum likelihood estimation to fit a binormal ROC curve to:
ROCKIT also calculates the statistical significance of differences between ROC index estimates and parameters. On the basis of a "bivariate binormal" model, it allows for comparison of 2 paired, partially paired, or unpaired datasets (which would represent, for example, different imaging modalities or diagnostic tests) with regard to:
Platforms: Mac and WindowsReferences: ROCKIT REPLACES ROCFIT, LABROC, CORROC2, CLABROC and INDROC. If the functionality of any of these programs is required, ROCKIT should be used instead. None of the older programs will be updated or modified in the future. ROCKIT employs our LABROC5 algorithm, a quasimaximum likelihood approach, to analyze continuously distributed data. The statistical tests performed by ROCKIT allow the conclusions of a study to be generalized to a population of cases, but not to a population of readers. If generalization to populations of both of readers and cases are required, the programs DBM MRMC 2.1 or LABMRMC should be used instead. New ROCKIT1.1B2, beta version, for Windows available (more stable, more cases can be used) 

MRMC 2.1 B 2 
Brief Description MRMC uses the DorfmanBerbaumMetz algorithm to compare multiple treatments (e.g., imagining modalities) by using data from multiple readers and multiple cases. This program employs jackknifing and ANOVA techniques. This software is will replace LABMRMC completely in the near future. Improvements to the algorithm are:
Platforms: Currently only Windows (others will follow) References: This program allows the conclusions drawn from a study to be generalized to both a population of readers and a population of cases The program requires that the Microsoft .NET Framework Version 1.1 be installed on the system. You can visit http://msdn.microsoft.com/netframework/downloads/howtoget.aspx
to check whether you have the .NET framework
installed and to view instructions for downloading it via Windows
Update. Read the user's guide for additional instructions. The user's guide is available at the download page and it is also included in the DBM MRMC installer package.


LABMRMC 
Brief Description LABMRMC uses the DorfmanBerbaumMetz algorithm to compare multiple treatments (e.g., imagining modalities) by using data from multiple readers and multiple cases. This program employs jackknifing and ANOVA techniques. Platforms: Mac and Windows References: This program allows the conclusions drawn from a study to be generalized to both a population of readers and a population of cases 

LABROC4 
Brief DescriptionLABROC4 uses maximum likelihood estimation to fit a single conventional binormal ROC curve to continuouslydistributed data (e.g., probability assessment on a 0100 scale or numerical output from a laboratory measurement such as blood count).This program provides standard error estimates that can be used to evaluate the statistical significance of the differences between unpaired ROC estimatesPlatforms: Linux and Mac, available only through direct requestReferences: This program uses a true maximumlikelihood approach rather than the quasimaximum likelihood approach (LABROC5) that is used in ROCKIT. It will be phased out and incorporated into ROCKIT at some point in the near future. 

PROPROC 
Brief Description PROPROC fits a single ROC curve by maximumlikelihood estimation (given ordinal category data) or by quasi maximumlikelihood estimation (given continuouslydistributed data). However, unlike ROCKIT or LABROC4, PROPROC employs a "proper" binormal model that always provides convex fitted curves. Thus, this program allows the fitting of degenerate data sets (datasets which can be fit with vertical and horizontal straight line segments, which are impossible to fit using the conventional binormal model) and data sets that would yield nonmonotonic (i.e., nonconvex) fits with the conventional binormal model. This program provides standard error estimates that can be used to evaluate the statistical significance of the differences between unpaired ROC estimates Platforms: Linux, Mac and Windows, available only through direct requestReferences This program is unique among our ROC software in the sense that it is the only program that employs the "proper" binormal model 
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This site was last updated 02/27/07